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Company ReportsAlnylam Pharmaceuticals

Alnylam Pharmaceuticals(ALNY)

Alnylam Pharmaceuticals, Inc. is an American biopharmaceutical company focused on the discovery, development and commercialization of RNA interference (RNAi) therapeutics for genetically defined diseases. The company was founded in 2002 and is headquartered in Cambridge, Massachusetts. In 2016, Forbes included the company on its "100 Most Innovative Growth Companies" list.

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Include Generics:

Trade Name	Drug Name	Approved	Patent Expires	Indication
Amvuttra	Vutrisiran	2022-06-13	2028-2036	Familial amyloid neuropathies
Givlaari	Givosiran	2019-11-20	2024-2034	Hepatic porphyrias
Onpattro	Patisiran	2018-08-10	2025-2035	Familial amyloidosis
Oxlumo	Lumasiran	2020-11-23	2028-2038	Primary hyperoxaluria

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

rnai therapeutics

,

,

nephrolithiasis

,

,

chronic renal insufficiency

,

kidney diseases

,

cardiovascular diseases

,

heart disease risk factors

,

,

,

primary hyperoxaluria

erythropoietic porphyria

,

,

acute intermittent porphyria

,

hereditary coproporphyria

,

hepatic porphyrias

,

variegate porphyria

,

polyneuropathies

,

familial amyloid neuropathies

,

familial amyloidosis

,

amyloid neuropathies

,

takotsubo cardiomyopathy

,

cardiomyopathies

,

disease progression

Givosiran sodium

erythropoietic porphyria

,

,

acute intermittent porphyria

,

hereditary coproporphyria

,

hepatic porphyrias

,

variegate porphyria

,

familial amyloid neuropathies

,

takotsubo cardiomyopathy

,

cardiomyopathies

,

familial amyloidosis

healthy volunteers/patients

,

nephrotic syndrome

,

,

hypertrophic cardiomyopathy

,

cardiomyopathies

,

,

peripheral nervous system diseases

,

diabetic neuropathies

,

,

postherpetic neuralgia

,

,

acute coronary syndrome

,

myocardial ischemia

,

sickle cell anemia

,

breast neoplasms

,

male breast neoplasms

,

,

chronic renal insufficiency

,

hypercholesterolemia

,

myocardial infarction

,

,

inferior wall myocardial infarction

,

,

,

essential hypertension

,

systolic murmurs

,

diabetes mellitus

,

kidney diseases

,

metabolic syndrome

,

,

,

type 2 diabetes mellitus

,

left ventricular hypertrophy

,

diabetic nephropathies

,

systolic heart failure

,

isolated systolic hypertension

,

hypersensitivity

,

,

,

diastolic heart failure

,

,

insulin resistance

,

,

,

left ventricular dysfunction

,

mitral valve insufficiency

,

ventricular dysfunction

,

glomerulonephritis

,

iga glomerulonephritis

,

membranous glomerulonephritis

,

focal segmental glomerulosclerosis

,

nephrosclerosis

,

coronary artery disease

,

atrial fibrillation

,

glucose intolerance

,

prehypertension

,

,

angina pectoris

,

microvascular angina

healthy volunteers/patients

,

,

inclusion body myositis

,

hemolytic-uremic syndrome

,

atypical hemolytic uremic syndrome

,

kidney diseases

,

glomerulonephritis

,

iga glomerulonephritis

,

,

,

,

paroxysmal hemoglobinuria

,

,

myasthenia gravis

,

muscle weakness

,

macular degeneration

,

geographic atrophy

,

,

chronic hepatitis c

,

,

,

healthy volunteers/patients

,

,

,

,

neuroendocrine tumors

,

neoplasm metastasis

,

,

b-cell chronic lymphocytic leukemia

,

multiple hamartoma syndrome

,

carcinoid tumor

,

aplastic anemia

,

,

oligodendroglioma

,

,

,

,

cerebellar neoplasms

,

brain neoplasms

,

hepatocellular carcinoma

,

endometrial neoplasms

,

pancreatic neoplasms

,

neuroendocrine carcinoma

,

islet cell carcinoma

,

atopic dermatitis

,

,

,

hodgkin disease

,

,

rheumatoid arthritis

,

,

thrombocytopenic purpura idiopathic

,

thrombocytopenia

,

neurofibromatosis 2

,

neurofibromatosis 1

,

neurofibromatoses

,

,

t-cell lymphoma

,

t-cell lymphoma peripheral

,

t-cell lymphoma cutaneous

,

tuberous sclerosis

,

urinary bladder neoplasms

,

transitional cell carcinoma

,

,

,

myeloproliferative disorders

,

essential thrombocythemia

,

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

non-hodgkin lymphoma

,

mantle-cell lymphoma

,

colorectal neoplasms

,

kidney neoplasms

,

,

,

multiple myeloma

,

plasma cell neoplasms

,

,

,

psoriatic arthritis

,

renal cell carcinoma

,

,

,

,

,

,

,

meningococcal meningitis

,

prostatic neoplasms

,

organ transplantation

,

graft rejection

,

pulmonary arterial hypertension

,

familial primary pulmonary hypertension

,

paroxysmal hemoglobinuria

,

,

chronic urticaria

,

,

hypersensitivity

,

food hypersensitivity

,

peanut hypersensitivity

,

juvenile arthritis

,

,

hereditary autoinflammatory diseases

,

,

familial mediterranean fever

,

,

,

,

,

,

attention deficit disorder with hyperactivity

,

,

,

major depressive disorder

,

depressive disorder

,

,

chronic hepatitis b

,

,

chronic hepatitis

,

heart transplantation

,

bone resorption

,

,

,

myeloid leukemia

,

kidney transplantation

,

breast neoplasms

,

,

bcr-abl positive chronic myelogenous leukemia

,

meningococcal infections

,

,

sickle cell anemia

,

liver transplantation

,

multiple sclerosis

,

chronic obstructive pulmonary disease

,

,

obstructive lung diseases

,

gastrointestinal stromal tumors

,

myeloid leukemia acute

,

human influenza

,

macular degeneration

,

lymphoid leukemia

,

,

,

alzheimer disease

,

choroidal neovascularization

,

pathologic neovascularization

,

,

beta-thalassemia

,

,

parkinson disease

,

relapsing-remitting multiple sclerosis

,

dry eye syndromes

,

type 2 diabetes mellitus

,

diabetes mellitus

,

polycythemia vera

,

primary myelofibrosis

,

graft vs host disease

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

myeloid leukemia chronic-phase

,

,

myelodysplastic syndromes

,

,

,

wet macular degeneration

,

,

,

cystic fibrosis

,

allergic bronchopulmonary aspergillosis

,

pulmonary aspergillosis

,

retinal detachment

,

vascular diseases

,

dissociative disorders

,

polypoidal choroidal vasculopathy

,

diabetic retinopathy

,

pneumococcal infections

,

hemochromatosis

,

,

philadelphia chromosome

,

,

stomach neoplasms

,

,

ankylosing spondylitis

,

spondylarthritis

,

healthy volunteers/patients

,

hyperlipidemias

,

hyperlipoproteinemias

,

,

,

chronic renal insufficiency

,

kidney diseases

,

Alpha1-proteinase inhibitor

,

orthostatic hypotension

,

prehypertension

,

abdominal obesity

,

essential hypertension

,

left ventricular hypertrophy

,

,

,

,

type 2 diabetes mellitus

,

diabetes mellitus

Sodium chloride

,

,

,

,

,

,

depressive disorder

,

,

streptococcal infections

,

streptococcus agalactiae

,

,

acute kidney injury

,

wounds and injuries

,

,

,

aplastic anemia

,

,

hematologic neoplasms

,

,

cutaneous malignant melanoma

,

major depressive disorder

,

suicidal ideation

,

stomach neoplasms

,

bacterial infections

,

gram-positive bacterial infections

,

diabetic nephropathies

,

allergic rhinitis

,

,

allergic rhinitis seasonal

,

,

parkinson disease

,

healthy volunteers/patients

,

peritoneal neoplasms

,

intestinal obstruction

,

triple negative breast neoplasms

,

complex regional pain syndromes

,

reflex sympathetic dystrophy

,

somatoform disorders

,

,

,

congenital hyperinsulinism

,

nesidioblastosis

,

hyperinsulinism

,

,

eosinophilic esophagitis

,

,

sickle cell anemia

,

treatment-resistant depressive disorder

,

meningococcal infections

,

,

hypercholesterolemia

,

hyperlipoproteinemia type ii

,

,

,

non-small-cell lung carcinoma

,

,

homozygous familial hypercholesterolemia

,

,

meningococcal meningitis

,

cardiovascular diseases

,

,

kidney diseases

,

renal cell carcinoma

,

,

cystic fibrosis

,

prostatic neoplasms

,

,

,

pancreatic neoplasms

,

chronic renal insufficiency

,

kidney transplantation

,

graft rejection

,

,

,

,

,

japanese encephalitis

,

respiratory tract infections

,

,

,

metabolic bone diseases

,

,

,

pulmonary eosinophilia

,

hepatocellular carcinoma

,

liver neoplasms

,

gastrointestinal stromal tumors

,

atherosclerosis

,

,

,

diabetes complications

,

vitreous hemorrhage

,

,

essential hypertension

,

metabolic syndrome

,

,

,

systolic murmurs

,

isolated systolic hypertension

,

neoplasm metastasis

,

,

human influenza

,

diabetes mellitus

,

multiple myeloma

,

plasma cell neoplasms

,

breast neoplasms

,

hypersensitivity

,

left ventricular hypertrophy

,

,

,

,

communicable diseases

,

,

diabetic retinopathy

,

,

insulin resistance

,

prehypertension

,

staphylococcal skin infections

,

infectious skin diseases

,

bacterial skin diseases

,

,

,

type 2 diabetes mellitus

,

,

,

retinal diseases

,

hip osteoarthritis

,

,

food hypersensitivity

,

abdominal obesity

,

retinal neovascularization

,

pathologic neovascularization

,

migraine disorders

,

migraine without aura

,

angina pectoris

,

microvascular angina

,

,

migraine with aura

,

health risk behaviors

,

vascular stiffness

healthy volunteers/patients

,

hepatic insufficiency

,

esophageal neoplasms

,

,

,

small cell lung carcinoma

,

pancreatic ductal carcinoma

,

multiple myeloma

,

plasma cell neoplasms

,

bronchiolitis obliterans syndrome

,

congenital abnormalities

,

chromosome aberrations

,

brain stem neoplasms

,

chronic hepatitis c

,

chronic hepatitis

,

,

,

medulloblastoma

,

,

,

choroid plexus neoplasms

,

primitive neuroectodermal tumors

,

,

,

neuroepithelial neoplasms

,

ganglioneuroblastoma

,

neuroectodermal tumors

,

phenylketonurias

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

nasopharyngeal carcinoma

,

ureteral neoplasms

,

pelvic neoplasms

,

adenoid cystic carcinoma

,

metabolic syndrome

,

follicular lymphoma

,

,

pancreatic neoplasms

,

kidney neoplasms

,

,

prostatic neoplasms

,

,

,

head and neck neoplasms

,

neurofibromatoses

,

,

liver neoplasms

,

,

,

neurofibromatosis 1

,

plexiform neurofibroma

,

systemic scleroderma

,

diffuse scleroderma

,

b-cell chronic lymphocytic leukemia

,

,

hematologic neoplasms

,

endometrial neoplasms

,

neuroendocrine carcinoma

,

central nervous system neoplasms

,

ovarian neoplasms

,

mantle-cell lymphoma

,

urinary bladder neoplasms

,

squamous cell carcinoma

,

uterine cervical neoplasms

,

myelodysplastic syndromes

,

non-hodgkin lymphoma

,

nervous system neoplasms

,

hypereosinophilic syndrome

,

systemic mastocytosis

,

,

uveal neoplasms

,

squamous cell carcinoma of head and neck

,

t-cell lymphoma

,

transitional cell carcinoma

,

primary myelofibrosis

,

,

graft vs host disease

,

adenocarcinoma of lung

,

diffuse intrinsic pontine glioma

,

disease progression

,

oligodendroglioma

,

neurofibromatosis 2

,

acoustic neuroma

,

,

hodgkin disease

,

islet cell carcinoma

,

hematologic diseases

,

myeloid leukemia accelerated phase

,

,

mast-cell leukemia

,

,

germ cell and embryonal neoplasms

,

,

anaplastic thyroid carcinoma

,

t-cell lymphoma peripheral

,

waldenstrom macroglobulinemia

,

castration-resistant prostatic neoplasms

,

,

cholangiocarcinoma

,

chronic disease

,

large-cell lymphoma anaplastic

,

plasma cell granuloma

,

,

,

,

,

gouty arthritis

,

endocrine gland neoplasms

,

,

urogenital neoplasms

,

male genital diseases

,

prostatic diseases

,

abdominal neoplasms

,

male genital neoplasms

,

genital diseases

,

sjogren's syndrome

,

retinitis pigmentosa

,

,

,

giant cell tumors

,

pigmented villonodular synovitis

,

giant cell tumor of tendon sheath

,

choroidal neovascularization

,

pathologic neovascularization

,

hemangioblastoma

,

von hippel-lindau disease

,

inflammatory breast neoplasms

,

invasive hydatidiform mole

,

multidrug-resistant tuberculosis

,

local neoplasm recurrence

,

t-cell lymphoma cutaneous

,

peutz-jeghers syndrome

,

acute coronary syndrome

,

st elevation myocardial infarction

,

malignant mesothelioma

,

,

type 1 diabetes mellitus

,

,

intestinal neoplasms

,

testicular neoplasms

,

,

brain stem infarctions

,

,

sturge-weber syndrome

,

klippel-trenaunay-weber syndrome

,

neurofibrosarcoma

,

nerve sheath neoplasms

,

carcinoma in situ

,

breast diseases

,

multiple hamartoma syndrome

,

,

urologic neoplasms

,

fallopian tube neoplasms

,

t-cell leukemia

,

localized scleroderma

,

myelomonocytic leukemia chronic

,

myelomonocytic leukemia acute

,

myelomonocytic leukemia juvenile

,

,

,

ovarian epithelial carcinoma

,

sickle cell anemia

,

streptococcus agalactiae

,

colorectal neoplasms

,

myeloid leukemia acute

,

,

,

neoplasm metastasis

,

brain neoplasms

,

hepatocellular carcinoma

,

,

thyroid neoplasms

,

thyroid diseases

,

chronic urticaria

,

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

,

triple negative breast neoplasms

,

,

colonic neoplasms

,

,

carcinoid tumor

,

pulmonary arterial hypertension

,

familial primary pulmonary hypertension

,

,

gastrointestinal neoplasms

,

stomach neoplasms

,

rectal neoplasms

,

,

meningococcal meningitis

,

meningococcal infections

,

rheumatoid arthritis

,

organ transplantation

,

graft rejection

,

digestive system neoplasms

,

cutaneous malignant melanoma

,

,

lymphangioleiomyomatosis

,

lupus nephritis

,

,

hypersensitivity

,

peanut hypersensitivity

,

multiple sclerosis

,

relapsing-remitting multiple sclerosis

,

interstitial lung diseases

,

,

lung transplantation

,

malignant carcinoid syndrome

,

serotonin syndrome

,

food hypersensitivity

,

psoriatic arthritis

,

,

muscular atrophy

,

spinal muscular atrophy

,

,

,

,

idiopathic pulmonary fibrosis

,

pulmonary fibrosis

,

,

chronic inducible urticaria

,

infectious skin diseases

,

bacterial skin diseases

,

,

,

myeloid leukemia

,

,

bcr-abl positive chronic myelogenous leukemia

,

breast neoplasms

,

,

,

non-small-cell lung carcinoma

,

renal cell carcinoma

,

,

kidney transplantation

,

philadelphia chromosome

,

lymphoid leukemia

,

neuroendocrine tumors

,

gastrointestinal stromal tumors

,

precursor cell lymphoblastic leukemia-lymphoma

,

,

myeloid leukemia chronic-phase

,

liver transplantation

,

renal insufficiency

,

tuberous sclerosis

,

chronic kidney failure

,

heart transplantation

,

kidney diseases

,

islet cell adenoma

,

,

,

macular degeneration

,

,

,

,

autosomal dominant polycystic kidney

,

communicable diseases

,

polycystic kidney diseases

,

,

diabetes mellitus

,

tick-borne encephalitis

,

,

immunosuppression therapy

,

cytomegalovirus infections

,

,

large cell carcinoma

,

vascular diseases

,

,

,

vision disorders

,

,

type 2 diabetes mellitus

,

cross-sectional studies

,

,

polyomavirus infections

,

cryopyrin-associated periodic syndromes

,

polycythemia vera

,

,

,

systolic heart failure

,

myocardial infarction

,

,

,

inferior wall myocardial infarction

,

polyneuropathies

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